So with two months of follow-up data in people undergoing those clinical trials, and now even longer follow-up from the trials and our experience giving vaccines to the public, we really are not seeing any trend toward any long-term side effects. Long-term side effects are just basically unheard of in the vaccine world.
And we have a lot of experience with different vaccines. We really have not seen long-term side effects from COVID-19 vaccines beyond that, and that makes sense when you look at other vaccines. At most, those side effects can last up to a week. The vaccine side effects that we've seen in these large phase three trials resolve within about 72 hours of taking a COVID-19 vaccine. How long could symptoms or side effects of COVID-19 vaccination last? It's kind of like they've studied for the test. The second vaccine dose goes into your body, starts to make that spike protein, and your antibodies jump on it and rev up your immune system response. Your body is primed by that first dose of vaccine. Then when you come back with a second dose, your body is ready to attack it. When you take two doses of a COVID-19 vaccine, the first dose is the first time for your body to see the spike protein that the COVID-19 vaccines produce, and your body begins to develop an immune response. Why are some people more likely to experience side effects after the second dose of a COVID-19 vaccine? Our bodies react, and that gives us these general symptoms like fever, achiness and headache. Actually, a lot of the symptoms from illnesses that we get, like influenza and COVID-19, are actually not caused by the direct action of the virus, but rather by our immune system. When you get sick, the same thing happens. The reason that we get side effects is that our immune system is revving up and reacting. When we get vaccinated for COVID-19, we often experience some side effects. Why do people experience side effects from COVID-19 vaccines? Melanie Swift, co-chair of the COVID-19 Vaccine Allocation and Distribution Work Group at Mayo Clinic, explains why vaccine side effects happen and what is known about symptoms following COVID-19 vaccination: Please courtesy: "Melanie Swift, M.D./COVID-19 Vaccine Allocation and Distribution/Mayo Clinic." Swift are available in the downloads at the end of the post.
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